Jim Brase is the Deputy Associate Director for Computing at Lawrence Livermore National Laboratory. He leads LLNL research in the application of high-performance computing, large-scale data science, and simulation to a broad range of national security and science missions. Jim is co-lead of the ATOM Consortium for computational acceleration of drug discovery and on the leadership team of the COVID-19 HPC Consortium. Jim’s research interests focus on the intersection of machine learning, simulation and high-performance computing. He is currently leading efforts in large-scale computing for life science, biosecurity and nuclear security applications. In his previous position as LLNL’s Deputy Program Director for Intelligence Jim led efforts in intelligence and cybersecurity R&D. He was formerly LLNL’s Division Leader for Optical Sciences and led programs in laser and imaging research at LLNL.