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XPSI: X-ray Free Electron Laser-Based Protein Structure Identifier
Event Type
Research Posters
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TimeThursday, 19 November 20208:30am - 5pm EDT
LocationPoster Module
DescriptionA protein's structure determines its function. Different proteins have different structures; proteins in the same family share similar substructures and thus may share similar functions. Additionally, one protein may exhibit several structural states, also named conformations. Identifying different proteins and their conformations can help solve problems such as determining the cause of diseases and designing drugs. X-ray Free Electron Laser (XFEL) beams are used to create diffraction patterns (images) that can reveal protein structure and function. The translation from diffraction patterns in the XFEL images to protein structures and functionalities is non-trivial. In this poster, we present the first steps into the design and assessment of a software framework for the identification of XFEL images. We call the framework XPSI (XFEL-based Protein Structure Identifier). We quantify the identification accuracy and performance of XPSI for protein diffraction imaging datasets including different protein orientations and conformations with realistic noise incorporated.
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