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DTSTAMP:20210402T160024Z
LOCATION:Poster Module
DTSTART;TZID=America/New_York:20201117T083000
DTEND;TZID=America/New_York:20201117T170000
UID:submissions.supercomputing.org_SC20_sess345_svs106@linklings.com
SUMMARY:Visualization of Flow of Circulating Tumor Cells and Blood Cell Su
 spensions in Microfluidics
DESCRIPTION:Posters, Scientific Visualization & Data Analytics Showcase\n\
 nVisualization of Flow of Circulating Tumor Cells and Blood Cell Suspensio
 ns in Microfluidics\n\nInsley, Hood, Tan, Rizzi, Knowles...\n\nIn this wor
 k, we present an explanatory visualization of a high-fidelity multiphysics
  simulation of circulating tumor cell (CTC) capture in a microfluidic devi
 ce. Detecting rare CTCs in the bloodstream is challenging but important fo
 r both clinical diagnostics and fundamental research. Microfluidics showed
  great promise in earlier CTC detection. To better understand the transpor
 t physics of CTCs in microfluidic devices, a high-performance computationa
 l model was used to investigate the role of micropost sizes and intercellu
 lar collisions on CTC transport and adhesion within the device. The visual
 ization illustrates that, overall, CTCs display transient rolling behavior
  in areas of high shear on microposts and firm adhesion in low-shear areas
 . The trajectories of CTCs can be seen closely following fluid streamlines
  at low RBC concentrations but deviating from streamlines at high RBC conc
 entrations due to the intercellular collisions. These behaviors are diffic
 ult or even impossible to observe without the use of visualization.\n\nReg
 istration Category: Tech Program Reg Pass, Exhibits Reg Pass
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